Welcome fellow friends! To end off Glycolysis we will be briefly discussing the feeder pathways. This topic is least important for our course but we should still briefly know something about it, so I posted this blog to help those struggling to get the gist of this topic.
Feeder Pathways for Glycolysis
In glycolysis most carbohydrates except glucose are transformed into one of the glycolytic intermediates. Listed below are the most significant:
1. The storage polysaccharides glycogen and starch
2. The disaccharides maltose, lactose, trehalose and sucrose
3. The monosaccharides fructose, mannose and galactose
Metabolism of Glucose
There are two routes in which fructose can be metabolized:
1. In adipose tissue
2. In the liver
Let’s see how in each case.
In adipose tissue: Fructose is phosphorylated to Fructose-6-phosphate that enters into glycolysis by muscle and kidney enzyme Hexokinase
In the liver: Fructose is metabolized by the Fructose-1-phosphate pathway by the enzyme Glucokinase.
Metabolism of Galactose
Galactose enters glycolysis via the galactose-glucose interconversion pathway which is a 4 step reaction sequence. See image below of this pathway.
Galactosemia is a genetic disease caused by the inability of the body to convert galactose to glucose this causes the buildup of galactitol which can have severe consequences to the individual.
Well guys, that ends glycolysis I hope you guys enjoyed and learnt something from the posts, activities and videos. Thanks again!